Seminar Series : Seminars Series I

The Rise of FGF23 from Mendelian Obscurity to Mainstream Cardiovascular Notoriety

The Rise of FGF23 from Mendelian Obscurity to Mainstream Cardiovascular Notoriety: A Case-Study in Translational Research

This presentation will track the discovery of a novel hormone from genomic investigation of rare hereditary diseases, its subsequent characterization as a critical regulator of phosphate metabolism in health and disease, and finally, its emergence as a novel mechanism of cardiovascular disease and powerful prognostic risk factor of adverse clinical outcomes.  The case-study will emphasize the complementary roles that a vast portfolio of study types played in the scientific development of this novel hormone: genomic studies, intense patient-oriented physiological studies, large epidemiological cohort studies and in vitro and animal models.