Seminar Series : Seminars Series I

Daniel Armstrong, PhD

Translational Science: From Concept to Clinic; From Clinic to Public Policy

Translational Science: From Concept to Clinic;From Clinic to Public Policy

Beginning in 2004,the NIH Roadmap began an expansion of health research from isolated laboratories to clinical application of research findings. This new model, termed translational research, offers many extensive opportunities, but also comes with challenges as scientists and systems adapt to the new model.  In their presentation, Drs. Armstrong and Hare will review some of the possibilities that a focus on translational science and interdisciplinary collaboration offer in the search to improve health, and for the research community at the University of Miami.  The opportunities for basic scientists, clinical researchers, community investigators, and public policy researchers to contribute to a continuum of translational science activities will be reviewed.

Claes Wahlestedt, MD, PhD

Noncoding RNA and the Transcriptional Landscape In Mammals

Noncoding RNA and the Transcriptional Landscape In Mammals

For many years, scientists believed that most of the unexplored “dark matter” of the human genome was non-functional, or “junk.” The idea of “junk DNA” generated on the belief that most genetic information is transacted via proteins, an assumption that dates back about half a century. New research, however, has shown that this junk may serve a significant purpose. Although this field is still in its infancy, scientists have already made significant progress towards discovering the purpose of this DNA. Dr. Wahlestedt will explore these findings, as they relate to the processes of the brain and the evolutionary goals of higher life forms.

Alan Delamater, PhD

Translational Research: What Do Grant Reviewers Look For?

Translational Research: What Do Grant Reviewers Look For?

Learn about the key elements of successful grant applications to conduct translational research in community settings.  These include the importance of the issue and efficacy of the intervention approach; use of theory; sampling and randomization plans; patients and settings; study design and control groups; process and outcome measures; statistical issues; feasibility; and external validity and potential for translation.

Richard J. Cote, MD

Nanotechnology In Translational Research

Nanotechnology In Translational Research

Recent years have seen great excitement in the development and use of nanoscale materials and devices, which have the potential to bring about a variety of transformative changes to clinical practice. The Biomedical Nanotechnology Institute of University of Miami (BioNIUM) works to encourage interaction and collaborative research between the biomedical researchers and physical science researchers in the use of these nanoscale materials to best address specific biomedical problems. Dr. Cote’s lecture will highlight such research at UM and through collaborations with researchers at other national institutions.

Nicholas Tsinoremas, PhD

Team Science: An Emerging Trend To Advance Translational Research

Team Science: An Emerging Trend To Advance Translational Research

This talk will discuss how to prepare yourself for team science, build a research team, develop and communicate a shared vision, handle conflicts and share credit and recognition. The increasing specialization of modern research and the complexity of today’s most pressing health issues have heightened the need to form teams of scientists trained in different fields. Given these trends, most researchers will likely find themselves asked to participate in or lead a research team at some point in their careers.

Ian McNiece, PhD

Regulatory Issues In Human Subjects Research

Regulatory Issues in Human Subjects Research

The conduct of clinical studies requires approvals by regulatory bodies such as the FDA and an Institutional Review Board (IRB). Investigators must ensure that their study protects the rights, safety, and welfare of its subjects. This presentation will provide an overview of the steps involved in submitting an IND/IDE application to the FDA, and will discuss the responsibilities of investigators in the execution of the trials.  

Kenneth W. Goodman, PhD

Ethics In Translational Science

Ethics In Translational Science

The foundations of evidence-based practice lay bare the need for clinicians to be aware of applicable contemporary research and for researchers to know the needs of clinicians. This bidirectional relationship has grown in complexity, and this has in turn made plain a number of ethical issues. Among these: effective collection, management and analysis of genetic data, the use of intelligent machines in those activities and the role of  public policy in advancing translational science. Along the way, we learn we must improve our collective ability to make judgments under uncertainty. Topics to  be addressed include ethics and data mining, communicating genetic findings to patients and the use of electronic health records as sources of research data.

Ana Palacio, MD, MPH

Translation Research in Health Disparities

Translation Research in Health Disparities

This presentation will describe the positive impact that translational research has on the health disparities reduction. Dr. Palacio will discuss the challenges translational research poses and suggest novel strategies to overcome them. She will also present real world knowledge that can help investigators identify sustainable solutions for health disparities.

Myles Wolf, MD, MMSc

The Rise of FGF23 from Mendelian Obscurity to Mainstream Cardiovascular Notoriety

The Rise of FGF23 from Mendelian Obscurity to Mainstream Cardiovascular Notoriety: A Case-Study in Translational Research

This presentation will track the discovery of a novel hormone from genomic investigation of rare hereditary diseases, its subsequent characterization as a critical regulator of phosphate metabolism in health and disease, and finally, its emergence as a novel mechanism of cardiovascular disease and powerful prognostic risk factor of adverse clinical outcomes.  The case-study will emphasize the complementary roles that a vast portfolio of study types played in the scientific development of this novel hormone: genomic studies, intense patient-oriented physiological studies, large epidemiological cohort studies and in vitro and animal models.

W. Dalton Dietrich, PhD

Protection and Repair After Spinal Cord Injury:  Recent Basic and Clinical Findings

Protection and Repair After Spinal Cord Injury:  Recent Basic and Clinical Findings

Over the last 25 years, researchers at The Miami Project to Cure Paralysis have concentrated their efforts on investigating the pathophysiology of spinal cord injury with a long-term goal of developing treatments to promote functional recovery in people living with paralysis.  This lecture will summarize some of these programs and emphasize the progress being made in the field of CNS injury and repair.